Journal: Advanced Science

Article Title: A Combination Therapy Using Electrical Stimulation and Adaptive, Conductive Hydrogels Loaded with Self‐Assembled Nanogels Incorporating Short Interfering RNA Promotes the Repair of Diabetic Chronic Wounds

doi: 10.1002/advs.202201425

Figure Lengend Snippet: a) The immunofluorescent staining of the Col I, VEGF, and CD31 expressed on day 7 in the diabetic chronic wounds and the laser speckle contrast imaging (LSCI) images of the defects collected on days 3 and 7. The scale bar represents a 20 µm scale. The scale bar represents a 20 µm scale. The amounts of the b) Col I, c) VEGF, and d) CD31 expressed in the skin tissues of the diabetic chronic wounds. The intensities of the fluorescent signals in the wounds in the control groups were set to 100% (***: p < 0.001, n = 3). e) The perfusion indexes of the diabetic chronic wounds in different groups (**: p < 0.01, ***: p < 0.001, n = 3). f) The mechanism for the repair of diabetic wounds using the combination of ES therapy and PHTB(TA‐siRNA) hydrogels.

Article Snippet: Immunofluorescence double staining: α ‐SMA (bsm‐33188 M, Bioss)/CD31 (GB11063‐2, Servicebio) and Col I (14695‐1‐AP, Proteintech)/Vimentin (GB12192, Servicebio)).

Techniques: Staining, Imaging